be popular to和be popular with的区别只有一个：

1、be popular to是指相对于某些东西或者人来讲会更流行或者出名。

如：It's popular to care about the quality of our life.

现在热门越来越关心生活的质量。

2、be popular with是指同某些东西或者人来讲一样流行或者出名。

如：Miss Brown is a popular teacher.

布朗小姐是位广受欢迎的教师。

be popular with受……欢迎 更多人会用be popular with

例如：Loud music is more popular with young people than with old.